What is cecal ligation and puncture?

The most widely used clinical model is cecal ligation and puncture (CLP). The CLP model consists of the perforation of the cecum allowing the release of fecal material into the peritoneal cavity to generate an exacerbated immune response induced by polymicrobial infection.

What is CLP disease?

Cecum Ligation and Puncture (CLP)-Induced Sepsis Model Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory responses followed by immunosuppression, which remains a major challenge for scientists and clinicians.

What is CLP sepsis?

The cecal ligation and puncture (CLP) method is a commonly used procedure for modeling sepsis in vivo. As the cecum is full of bacteria, its puncture results in polymicrobial peritonitis, translocation of bacteria into the blood (bacteremia), septic shock, multi-organ dysfunction and, ultimately, death5.

Can the cecal ligation and puncture model be repurposed to better inform therapy in human sepsis?

The most commonly used animal model to study the pathogenesis of human sepsis is cecal ligation and puncture (CLP) in mice. The model has been the mainstay of sepsis research for decades and continues to be considered the gold standard to inform novel pathways of sepsis physiology and its therapeutic direction.

Do humans have a cecum?

In humans, the cecum is involved in absorption of salts and electrolytes and lubricates the solid waste that passes into the large intestine.

What happens when your cecum is removed?

In our study we demonstrated that removal of the cecum resulted in a conspicuous decrease in both richness and evenness of bacterial communities of the colon, as well as a pronounced change in the composition of the bacterial community structure.

What is life expectancy after colon surgery?

The overall survival rate after colectomy. The 5-, 10-, 20-, and 30-year overall survival rates were 94.7%, 88.4%, 72.0%, and 72.0%, respectively. The overall survival rate after colectomy. The 5-, 10-, 20-, and 30-year overall survival rates were 94.7%, 88.4%, 72.0%, and 72.0%, respectively.

What is the survival rate after colon surgery?

Colon resection is a common operation that is associated with a mortality rate of 2% to 6%. Multiple studies have evaluated factors related to mortality after colectomy, including surgeon factors or hospital volume,7-9 while others have derived risk stratification models using patient comorbidities.