What is disulfiram effect?
What is disulfiram effect?
In medicine, the term “disulfiram effect” refers to an adverse effect of a particular medication in causing an unpleasant hypersensitivity to alcohol, similar to the effect caused by disulfiram administration.
How do you deal with disulfiram like reactions?
For patients with possible disulfiram-ethanol reaction (DER), provide supplemental oxygen, obtain intravenous access, and place all patients on a monitor. Administer thiamine, glucose, and naloxone to patients with altered mental status, as needed.
Which are symptoms of a disulfiram type reaction?
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.
How do you deal with disulfiram-like reactions?
What causes disulfiram-ethanol reaction?
The disulfiram-ethanol reaction (DER) is due to increased serum acetaldehyde concentrations generated by the metabolism of ethanol by alcohol dehydrogenase in the liver. Normally, this acetaldehyde is cleared rapidly by its metabolism to acetate via aldehyde dehydrogenase.
Does alcohol cause disulfiram-like reaction?
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others….
| Disulfiram-like drug | |
|---|---|
| Biological target | Acetaldehyde dehydrogenase, others |
| In Wikidata |
How does a disulfiram-like reaction occur?
The disulfiram-ethanol reaction is thought to occur by the accumulation of acetaldehyde secondary to inhibition of the aldehyde dehydrogenase enzyme, which may be deficient in many Asians, or another unknown toxic factor. This incapacitating reaction has been used to discourage chronic alcohol ingestion.
What meds cause disulfiram reaction?
Examples of drugs that have been reported to produce disulfaram-like reactions include metronidazole (Flagyl and other brands), trimethoprim-sulfamethoxazole (Bactrim, Bactrim DS), tinidazole, chlorpropamide (Diabinese), tolbutamide, and others.
How do you stop a disulfiram like reaction?
What is the management and disposition?
- There is no antidote for acute disulfiram overdose, chronic disulfiram overuse, or disulfiram-ethanol reaction. (
- Supportive care with fluids, antiemetics, and antihistamines is the mainstay treatment.